The Grandma with Inhaler is a meme from MrBeast. She seems to be an old lady with short and white hair that is wearing a white shirt and is using a white inhaler. She appeared in many of MrBeast's older vlogging/comedy videos before the expensive challenge/donation genre of videos. The person based on this sticker is currently unknown. She is the grandmother of the Giant Asian Sticker.
This meme originated with the popular YouTube group "Cowchop" in May of 2016 in their video "OWL PELLET DISSECTION", an episode of their "Amazon Prime Time" series in which James and Alex buy each other gifts from Amazon. This meme was made further popular a few months later in November of 2016 when MrBeast bought the poster in his video "WORST PRODUCTS EVER ON AMAZON".